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Test Code HYDCS Hydrocodone and Metabolites, Serum


Ordering Guidance


This test should only be ordered by healthcare professionals to monitor patients who have been prescribed hydrocodone.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Secondary ID

623451

Useful For

Monitoring therapeutic efficacy/compliance in serum specimens of patients who are prescribed hydrocodone

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Hydrocodone and metabolites, S

Specimen Type

Serum Red

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

Therapeutic range/Metabolite information (as applicable):

Hydrocodone: 10-100 ng/mL

Norhydrocodone: Metabolite of hydrocodone

Hydromorphone: 1.0-30 ng/mL when used as sole therapy; Metabolite of hydrocodone and minor metabolite of morphine

Dihydrocodeine: 72-150 ng/mL when used as sole therapy, Minor metabolite of hydrocodone

 

Cutoff concentrations:

Hydrocodone: 1.0 ng/mL

Norhydrocodone: 1.0 ng/mL

Hydromorphone: 1.0 ng/mL

Dihydrocodeine: 1.0 ng/mL

Day(s) Performed

Wednesday

Report Available

2 to 9 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

G0480

80361 (if appropriate for select payers)

Clinical Toxicology CPT Code Client Guidance

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HYDCS Hydrocodone and metabolites, S In Process

 

Result ID Test Result Name Result LOINC Value
623451 Hydrocodone - Free 12786-0
623452 Norhydrocodone - Free In Process
623453 Hydromorphone - Free 12787-8
623454 Dihydrocodeine - Free 12785-2